Controlling Cell Proliferation

Description
We study the function of individual proteins that are part of the nuclear pore complex --a multiprotein structure through which active transport of molecules from 9 nm to 40 nm diameter takes place between the nucleus and cytoplasm. We are interested in the interface between pore proteins and transport cargo as well as in non-canonical functions of pore proteins, such as a role we have found in nuclear membrane remodeling during cell division.

Implications
A better understanding of molecular events involved in intracellular transport and in division of the nucleus is important to understanding, and ultimately controlling, cell proliferation.

Research Group Contacts
Dr. Katharine Ullman, Dept. of Oncological Sciences http://www.hci.utah.edu/ullmanlab

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